在人类海马体和杏仁体中检测可预测和不可预测的偏差.
Athina Tzovara1,2,3, Tommaso Fedele4, Johannes Sarnthein4
1Helen Wills Neuroscience Institute, University of California, 450 Li Ka Shing Biomedical Center, Berkeley, CA 94720-3370, United States.
Cerebral cortex (New York, N.Y. : 1991)
|January 12, 2024
概括
大脑使用广泛的电路预测听觉事件. 海马追踪可预测性,而杏仁体对意想不到的声音做出反应,揭示了一个分布式预测网络.
科学领域:
- 神经科学是一个神经科学.
- 听觉感知是一种听觉感知.
- 预测编码 预测编码
背景情况:
- 大脑根据过去的经验形成预测,在皮层区域发现的预测电路.
- 在听觉预测中,像海马体和杏仁体这样的中间时结构的作用是未被充分探索的.
- 海马和杏仁体对可预测和不可预测的听觉刺激的反应的电生理学概况是未知的.
研究的目的:
- 研究海马和杏仁体对可预测和不可预测的偏差听力事件的电生理反应.
- 为了测试海马对可预测性和杏仁核对意想不到的偏差敏感的假设.
- 为了阐明听觉预测和预测错误信号在中间时结构的神经基础.
主要方法:
- 在可预测和不可预测的背景下向接受手术前监测的患者呈现标准和偏差的听觉刺激.
- 在皮质,杏仁体和海马体中分析了局部场潜力 (LFP).
- 检查了对听觉事件和偏差的特定频率反应 (1-20 Hz和1-8 Hz).
主要成果:
- 听觉反应和偏差效应在皮质中出现的时间比杏仁体和海马体更早.
- 侧側皮質顯示不論可預測性 (1-20 Hz LFPs) 的偏差效應.
- 杏仁体在不可预测的环境中表现出更强烈的偏差反应.
- 海马在可预测但不不可预测的环境中显示了低频偏差反应 (1-8 Hz).
结论:
- 听觉预测涉及到一个分布式网络,它超出了先前识别的皮质区域.
- 海马和杏仁体在处理听觉可预测性和偏差方面发挥着不同的作用.
- 这些发现需要对潜在的感官预测和预测错误信号的神经机制有更深入的了解.
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