冠状动脉复血管化手术后不良结果的性别特异性遗传风险
Jouko Marko Nurkkala1,2, Jenni Aittokallio1,2,
1Division of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland.
复血管化后心房 (AF) 的遗传风险在男性中较高,而女性的内出血 (ICH) 风险更高. 多遗传风险评分 (PRS) 可以识别这些性别特异性并发症的高遗传风险个体.
科学领域:
- 心血管遗传学 心血管遗传学
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 观察到重血管化后不良事件的性别差异,可能受遗传因素的影响.
- 了解这些性别特异性遗传倾向对于个性化风险评估和心血管患者的管理至关重要.
研究的目的:
- 为了研究多基因风险评分 (PRSs) 和冠状动脉再血管化后的主要不良心血管和脑血管事件之间的性别特定关联.
- 为了确定是否对心房 (AF) 和内出血 (ICH) 等疾病的遗传倾向在男性和女性之间不同.
主要方法:
- 包括5561名女性和17578名接受重血管化手术的男性.
- 进行了基因定型,并计算了各种结局的多基因风险得分 (PRS).
- 考克斯的比例危险模型与相互作用术语被用来分析PRS与不良事件之间的性别特异关联,包括AF,缺血性中风 (STR),ICH,心肌梗塞 (MI) 和胃肠道出血 (GIH).
主要成果:
- 心房动PRS (AF-PRS) 显示男性与女性相比与AF的相关性更强 (相互作用的P=0.006).
- 相反,女性的内出血PRS (ICH-PRS) 与男性的内出血更强烈相关 (相互作用P=0.008).
- 对于PRS与缺血性中风,心肌梗塞或胃肠道出血的关联,没有发现显著的性别差异.
结论:
- 在重血管化后,男性对AF的遗传倾向更大,而女性对ICH的遗传风险更高.
- 性别特定的PRS可以被潜在地用来识别那些有高基因风险的个体,这些性别特定的复发症.
- 这些发现支持在心血管保健中制定定制的遗传风险分层策略.
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