修改的兰金尺度在患有动脉瘤下关节出血的患者中的有效性:一项随机化研究
E Nobels-Janssen1,2, E N Postma3, I L Abma4
1Department of Neurology, Haga Teaching Hospital, The Hague, The Netherlands. edith.nobels-janssen@radboudumc.nl.
BMC neurology
|January 12, 2024
概括
修改后的兰金尺度 (mRS) 在动脉瘤下关节出血 (aSAH) 患者中显示出良好的收有效性,但缺乏响应性. 结构化面试最好地检测神经心理问题.
科学领域:
- 神经学 神经学
- 临床结果研究研究
背景情况:
- 修改后的兰金尺度 (mRS) 是临床医生报告的全球残疾结果指标.
- 在动脉瘤下关节出血 (aSAH) 患者中缺乏mRS的验证.
- 患者报告的结果指标 (PROM) 在评估康复方面越来越重要.
研究的目的:
- 在aSAH患者中评估mRS的融合有效性.
- 在这个人群中评估mRS的响应能力.
- 检查与PROMs相关的mRS分数的分布.
主要方法:
- 未来的,随机的,多中心研究设计.
- 医生的mRS得分,结构化面试和自我评估.
- 患者填写了EQ-5D-5L,RAND-36,SS-QoL和GPE的问卷.
- 用于评估融合有效性和响应性的假设测试.
主要成果:
- 包括149名aSAH患者.
- mRS显示与EQ-5D-5L (r=-0.546),RAND-36 (身体:r=-0.439,精神:r=-0.574) 和SS-QoL (r=-0.671) 有显著的相关性.
- 在四个融合有效性假设中,有三个符合;响应性假设中没有一个符合.
- 结构化访谈mRS与心理健康比身体健康相关性更好.
结论:
- 一般来说,mRS与aSAH患者的其他结果指标相关.
- 在这组患者中,mRS的反应能力有限.
- 建议对mRS进行结构化采访,以确定残疾的神经心理问题.
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