通过测量尿路生物标志物来检测低尿量
1Karolinska Institutet at Danderyds Hospital (KIDS), Stockholm, 182 88, Sweden. robert.hahn@ki.se.
BMC nutrition
|January 12, 2024
概括
低尿量 (<1L/24h) 可以通过尿液度和肌素生物标志物检测. 这些标志物表明水和卡路里摄入量减少,年龄影响尿量低的发生率.
科学领域:
- 临床生物化学 临床生物化学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年病的医生 老年病的医生
背景情况:
- 尿量低 (<1L/24h) 是一个关键的临床征兆,需要立即评估,以区分不充分的液体摄入量和脱水.
- 在不同的人群中,低尿量的流行率和可靠指标仍然不清楚.
研究的目的:
- 确定可靠的尿液生物标志物,以检测健康志愿者的低尿量 (<1L/24h).
- 评估减少水和卡路里摄入量对尿液输出的影响.
- 用验证的生物标志物评估年龄和临床环境对低尿量发生率的影响.
主要方法:
- 20名健康志愿者的队列在8天内监测每天的食物/水摄入量和尿液输出量.
- 第一个早晨的尿样被分析了度和肌素.
- 确定了最佳生物标志物截止值,并应用于来自不同临床环境的1,316名受试者的横截面数据,并未对年龄进行校正.
主要成果:
- 尿液度 (>760莫斯莫尔/公斤) 和尿液肌素 (>13毫莫尔/升) 准确地表示尿液输出<1L/24h,敏感度和特异性为~80%.
- 尿量低 (<1L) 的日子与显著减少的水 (-41%) 和卡路里 (-22%) 摄入量相关.
- 经年龄校正的生物标志物切断结果显示,尿量低与年龄之间存在更强的关联,影响了44%的年轻成年人 (15-30岁) 与18%的老年人 (90-104岁) 相比.
结论:
- 尿液度和肌素是年轻和中年人的尿量低 (<1L/24h) 的精确生物标志物.
- 在老年人群中进一步验证这些生物标志物截止值是必要的,以便可靠地评估脱水和流体状况.
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