五种不同的商用大麻衍生局部大麻产品的药理动力学和药理动力学
C Austin Zamarripa1, Hayleigh E Tilton1, Spencer Lin1
1Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr., Baltimore, MD 21224, USA.
Journal of analytical toxicology
|January 13, 2024
概括
局部使用的大麻二醇 (CBD) 产品显示了一些通过皮肤吸收,度在7-10天后达到峰值. 虽然delta-9-THC在血液中无法检测到,但一些参与者有阳性口服液体测试,尽管没有观察到显著的影响.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 皮肤病学和化品科学
- 大麻素研究 研究 大麻素研究
背景情况:
- 2018年农业法案使大麻合法化,导致大麻二醇 (CBD) 产品的激增,特别是主题产品.
- 对来自大麻的局部CBD产品的疗效和安全性的受控临床研究是有限的.
- 由于这些产品越来越受欢迎,了解这些产品的药理动力学和药理动力学至关重要.
研究的目的:
- 描述商业上可用的麻衍生局部CBD产品的急性和慢性影响.
- 评估CBD和delta-9-tetrahydrocannabinol (Δ9-THC) 的透皮吸收,代谢和潜在的药学动力学影响.
- 评估这些产品在健康成年人中的安全性和耐受性.
主要方法:
- 一项随机对照研究涉及46名健康成年人,他们使用了五种CBD局部配方之一 (奶油,乳液,贴片,乳液,凝) 或安慰剂.
- 一个17天的协议,包括急性应用,9天的门诊阶段,每天应用两次,以及1周的洗期.
- 分析全血,口腔液体和尿液样本,使用液体色谱与双重质谱 (LC-MS-MS) 分析CBD,Δ9-THC及其代谢物;还评估了药理学结果.
主要成果:
- 对三种产品观察到CBD的通过皮肤吸收,度在7-10天后达到峰值,在乳液配方中最高.
- Δ9-THC及其代谢物在血液中低于检测极限,并且没有尿液样本对大麻呈阳性.
- 九名参与者显示D9-THC口服液度高于联邦工作场所的值,但没有发现可辨认的药理动力学效应或不良事件.
结论:
- 由大麻衍生的局部CBD产品可以导致可测量的CBD的全身吸收,并且出乎意料地, Δ9-THC在口服液中.
- 这些产品没有产生显著的主观,认知,精神运动或生理影响,并且被很好地容忍.
- 需要进一步的研究来了解吸收的变化和潜在的影响,考虑到局部CBD产品的多样化市场.
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