周围血液天然杀手细胞的比例不是一个固体代孕免疫指数在不明原因的反复流产中
Niwei Yan1,2,3, Pingyin Lee1,2, Huiying Jie1,2
1Center for Reproductive Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Iranian journal of immunology : IJI
|January 13, 2024
概括
在不明原因的复发性流产 (uRM) 中,外围自然杀手 (pbNK) 细胞的数量可能与自身免疫反应有关,而不是直接原因. 自体抗体状态,特别是TPO-Ab和ANA,与pbNK细胞水平相关,这表明需要在免疫治疗中仔细解释.
科学领域:
- 生殖免疫学 生殖免疫学
- 这是一种自身免疫力.
- 具有天生的免疫力.
背景情况:
- 针对未解释的反复流产 (uRM) 的外围自然杀手 (pbNK) 细胞的免疫疗法正在争论中.
- 这项研究调查了pbNK细胞计数的变化是否是RMR中先天性免疫反应的结果,而不是原因.
研究的目的:
- 为了确定pbNK细胞计数是否在女性之间有所不同,无法解释的反复流产的女性对常见的自身免疫标志物进行了阳性或阴性测试.
- 探索RRM患者的特定自身抗体和pbNK细胞水平之间的关系.
主要方法:
- 从302名RMR患者的外周血液样本中分析了抗核抗体 (ANA),抗甲状腺过氧化酶抗体 (TPO-Ab) 和抗甲状腺球蛋白抗体 (Tg-Ab).
- 使用流细胞计量评估了pbNK细胞计数.
- 根据pbNK细胞数量 (高与正常) 分组患者,以比较自身抗体的流行率和相关性.
主要成果:
- 在TPO-Ab阳性和高pbNK细胞 (OR=5.097,p=0.016) 之间发现了积极的关联.
- 在ANA阳性和高pbNK细胞之间观察到负相关性 (OR=0.293,p=0.013).
- 与相应的负组相比,TPO-Ab阳性患者的pbNK细胞数量较高,而ANA阳性患者的pbNK细胞数量较低.
结论:
- 在RRM中pbNK细胞数量的变化可能是潜在免疫反应的结果,可能与自身免疫有关.
- 由于这些关联,pbNK细胞作为RRM中直接免疫治疗指数的作用需要仔细考虑.
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