左侧型活动影响了右侧性硬化症中语言侧面化
Juliana Passos de Almeida1,2, Bettina Martins Castro1,2, Valmir Passarelli1
1Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Epilepsia open
|January 13, 2024
概括
患有右侧状硬化症和左侧状排泄症的患者在中环中表现出改变的语言处理. 这表明患者的大脑网络重组.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 认知神经学 认知神经学
背景情况:
- 间歇性性硬化 (MTS) 是的常见原因,通常与认知和语言障碍有关.
- 语言处理通常侧向左半球,但这可能会受到神经疾病的影响,如MTS.
- 间接性发性泄露 (IED) 可能会影响大脑功能和网络组织.
研究的目的:
- 调查左侧型活动与右侧MTS患者的语言横向性指数 (LI) 之间的关系.
- 探索潜在的语言网络重组,以应对MTS患者的形异常.
主要方法:
- 功能性磁共振成像 (fMRI) 用于在响应性阅读命名任务中评估语言处理.
- 在使用fMRI数据计算多个感兴趣区域 (ROI) 的语言侧面性指数 (LI).
- 进行了长时间的视频脑电图 (视频EEG) 监测,以确定左侧间接性形放电 (IED) 的存在.
主要成果:
- 与没有左侧IED的患者相比,左侧IED的右侧MTS患者在中椎 (MTG) 中呈现较低的LI.
- 这种LI的减少表明MTG中的半球语言主导或激活模式发生了变化.
- 在其他ROI中没有观察到LI的显著差异,这突显了MTG的具体参与.
结论:
- 右侧MTS患者与左侧形IED显示语言网络重组,特别是在MTG内.
- 这种重组可能涉及左MTG激活的减少,右MTG激活的增加,或它们的组合.
- 这些发现强调了型活动对MTS语言处理和大脑网络适应性的影响.
关键词:
功能性磁共振成像技术 功能性磁共振成像技术语言重组语言重组这种疾病是 mesial temporal sclerosis,也就是 mesial 时硬化症.在叶发作.视频-EEG监控视频-EEG监控视频-EEG监控视频-EEG监控视频更多相关视频
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