代谢和内分泌状况与患有多囊性卵巢综合征的患者中阻断性睡眠呼吸暂停风险相关
Jacob P Christ1, Kanade Shinkai2, Jamie Corley1
1Center for Reproductive Health, University of California San Francisco, San Francisco, California.
概括
患有阻塞性睡眠呼吸暂停 (OSA) 高风险的多囊卵巢综合征 (PCOS) 患者表现出更高水平的失糖症,炎症和雄激素. 这些代谢和内分泌因素独立地预测PCOS妇女的OSA风险.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 在患有多囊性卵巢综合征 (PCOS) 的患者中,阻塞性睡眠呼吸暂停 (OSA) 的风险较高.
- 连接PCOS和OSA的生理机制仍然不清楚.
- 了解这些联系对于管理PCOS并发症至关重要.
研究的目的:
- 在被诊断为多囊性卵巢综合征 (PCOS) 的患者中确定阻塞性睡眠呼吸暂停 (OSA) 风险的预测因素.
- 调查PCOS患者中代谢和内分泌因素与OSA风险之间的关联.
主要方法:
- 对309名患有PCOS的成年女性患者进行了横截面分析.
- 患者使用柏林问卷 (BQ) 评估OSA风险.
- 进行了标准化的人类测量,内分泌和代谢表型.
主要成果:
- 根据BCQ,在接受查的PCOS患者中,33.7%的患者患有OSA的高风险.
- 高OSA风险与更高的腰部:部比率,胰岛素耐药性标记物,血红蛋白A1c,C反应蛋白和自由有关.
- 多变量分析确定了血红蛋白A1c,C反应蛋白和性激素结合球蛋白作为高OSA风险的独立预测因素.
结论:
- 低血糖,炎症和雄激素状况是PCOS女性OSA风险的独立预测因素.
- 这些发现强调了代谢和内分泌健康与PCOS睡眠障碍的相互联系.
- 需要进一步的研究来澄清PCOS患者OSA的临床影响和治疗策略.
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