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用GC×GC/TOF-MS对汇集的人类血清样本进行嫌疑人查分析

Katherine A Phillips¹, Alex Chao¹, Rebecca L Church²

¹U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, North Carolina 27711, United States.

Environmental science & technology

|January 13, 2024

概括

这项研究确定了人类血清中的500多种化学物质,其中许多是女性特有的,突出了需要风险评估的潜在暴露来源. 这项研究有助于推进环境健康和化学安全评估.

科学领域:

环境健康科学环境健康科学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

人类每天都会接触到各种各样的化学物质.
识别引起新兴关注的物质对于人类健康风险评估至关重要.
了解化学物质暴露需要先进的分析技术.

研究的目的:

在人血清样本中识别和量化化学物质.
为了研究化学暴露概况的性别特异性差异.
确定需要进一步评估健康风险的新兴污染物.

主要方法:

使用气体染色学-气体染色学/飞行时间质谱学 (GC × GC/TOF-MS) 分析组合的人类血清样本 (n=16).
嫌疑人的选分析,然后对19种物质进行有针对性的确认.
根据性别 (女性/男性) 和年龄 (≤45/>45) 的样本分层.
根据公开可用的暴露来源数据,对已识别的物质进行注释.

主要成果:

在人类血清中初步识别了544种独特物质.
在两性化学特征中观察到的显著差异:女性472,男性271.
在女性血清样本中发现了273种物质.
来自各种来源的化学物质的识别,包括食品,药物,商业和环境污染物.

结论:

人类血清含有复杂的化学物质混合物,在暴露中存在显著的性别特异性差异.
这些发现表明,存在与女性有独特相关的暴露源.
这项研究强调了化学风险评估和环境健康研究中需要考虑性别特异性的必要性.

关键词:

生物监测生物监测化学风险化学风险化学风险暴露的法医医学暴露的法医医学气相色谱是一种气相色谱.嫌疑人的查分析分析.

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