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与阿诺基斯相关的基因特征预测了存活率,并且与骨髓瘤中的免疫透相关

Junqing Li¹, Hui Wang¹, Feiran Wu¹

¹Minimally Invasive Spinal Surgery Center, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Zhengzhou 450018, China.

|January 13, 2024

概括

鉴定了与阿诺基斯相关的基因 (ARG),并用于构建模型,预测骨髓瘤的整体存活率 (OS) 和无复发存活率 (RFS). 基因O-GlcNAc转移酶 (OGT) 显示为潜在的生物标志物,抑制瘤入侵和迁移.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

阿诺基斯对恶性瘤的进展至关重要,但其在骨髓瘤中的作用尚不清楚.
识别参与阿诺基斯的关键基因对于了解骨髓瘤的发展和预后至关重要.

研究的目的:

在骨髓瘤中识别与瘤相关的基因 (ARG).
开发使用ARG的总生存率 (OS) 和无复发生存率 (RFS) 的预测模型.
研究ARG在骨髓瘤细胞迁移和侵入中的功能作用.

主要方法:

对公共数据集 (GSE16088,GSE28425) 进行广泛的生物信息学分析,以识别差异表达基因 (DEG) 和枢纽基因.
使用选定的ARG开发OS和RFS的预测模型.
用于临床预测的诺摩图构造.
在体外,Transwell测试评估O-GlcNAc转移酶 (OGT) 对细胞迁移和侵入的影响.

主要成果:

鉴定了7个枢纽基因和71个与阿诺基斯相关的DEG.
四个ARG (BRMS,COL4A2,FGF2,OGT) 形成了一个RFS预测模型;七个ARG (CD24,FASN,MMP2,EIF2AK3,ID2,PPARG,PIK3R3) 形成了一个OS预测模型.
高风险患者表现出明显较短的OS和RFS.
击败OGT抑制了骨髓瘤细胞的入侵和迁移.
瘤透免疫细胞与风险得分相关.

结论:

基于ARG的签名有效地预测骨髓瘤中的RFS和OS.
在骨髓瘤中,OGT显示出作为预后生物标志物和治疗点的潜力.
这项研究增强了对ARG在骨髓瘤的预后意义的理解.

关键词:

其他 OGT 产品.一个年轻的ikis anoikis 骨质肉瘤是骨质肉瘤的一种疾病.瘤免疫力免疫力

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