帕金森病主要是环境疾病
E Ray Dorsey1, Bastiaan R Bloem2
1Center for Health + Technology and Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
Journal of Parkinson's disease
|January 13, 2024
概括
农药,三乙烯和空气污染等环境毒素是全球帕金森病 (PD) 的主要驱动因素. 了解这些原因为预防大多数PD病例提供了希望.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 帕金森病 (PD) 正在全球范围内迅速增加.
- 虽然考虑了人口老龄化和遗传学,但环境因素越来越多地受到影响.
研究的目的:
- 调查环境毒素作为帕金森病的主要原因的作用.
- 评估 PD 发病率上升的替代解释.
主要方法:
- 审查科学文献,将环境暴露与PD联系起来.
- 对关键毒素的流行率和暴露途径的分析.
- 检查生物机制,包括线粒体功能障碍.
主要成果:
- 暴露于特定农药,三乙烯 (TCE) 和空气污染被确定为PD的主要原因.
- 这些有毒物质广泛存在,可以通过吸入和摄入进入人体.
- 线粒体功能障碍是受到这些环境因素影响的常见途径.
结论:
- 大多数帕金森病病例可以通过减少对环境有毒物质的暴露来预防.
- 缓解环境因素可能会导致PD患病率显著下降.
- 对环境原因的进一步研究可以为PD预防的公共卫生策略提供信息.
相关概念视频
01:24Parkinson's Disease: Treatment
272
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
272
01:15Parkinson's Disease: Overview
551
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
551
01:37Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:30Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68