一项前性的开放性剂量反应研究,以纠正肝硬化中维生素D缺乏症
Chip A Bowman1, Kian Bichoupan2, Shai Posner2
1Division of Digestive and Liver Diseases, Department of Medicine, Columbia University New York Presbyterian, New York, NY, USA.
Digestive diseases and sciences
|January 13, 2024
概括
维生素D3补充剂在肝硬化患者中安全增加了维生素D水平. 一个分层的剂量方案有效地提高了大多数参与者的25-氧维生素D [25(OH) D]度.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D缺乏症在晚期肝病中很常见.
- 在这些患者中,提高血清25-基维生素D [25(OH) D]的最佳维生素D3剂量尚未确立.
研究的目的:
- 确定肝硬化患者维生素D3和25 (OH) D水平之间的剂量反应关系.
- 为了评估分层维生素D3剂量方案的安全性和有效性.
主要方法:
- 一项涉及口服维生素D3补充剂 (4,000 IU/d或2,000 IU/d) 的开放性研究,在48名肝硬化患者中持续6个月.
- 测量了血清25 ((OH) D水平,并评估了坚持.
- 一般估计方程 (GEE) 用于剂量反应分析.
主要成果:
- 81%的患者在没有高血症的情况下达到25(OH) D水平>20 ng/mL.
- 较高的维生素D3剂量 (4,000 IU/d) 导致25...OH) D的增加大约增加了两倍.
- 平均增量增加为每1000IU/d维生素D3的5.1ng/mL,与专蛋白,血红蛋白,MELD得分和胆红素有显著的相关性.
结论:
- 两级的每日口服维生素D3剂量方案是安全有效的,用于提高25(OH) D度在大多数坚持肝硬化成年人中.
- 这种方法可以帮助解决这种患者群体的维生素D缺乏症.
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