设计和准备一种机电植入物原型,用于按需药物输送
Milad Saadatkish1, Erfaneh Ghassami2, Ehsan Foroozmehr3
1Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Journal of the mechanical behavior of biomedical materials
|January 13, 2024
概括
融合沉积建模 (FDM) 3D打印的机电植入物展示了优越的药物储存和机械抵抗力. 这种优化的植入物设计使得医生控制的药物释放成为可能,这标志着向药物输送系统的重大进步.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 生物植入物对于持续的药物输送至关重要,机电系统代表了新一代向方法.
- 整合电气和机械功能提供了在药物输送中加强的控制和应用潜力.
研究的目的:
- 设计和原型一个电机药物输送植入物,使用沉积建模 (FDM),选择性激光烧结 (SLS),和多喷射融合 (MJF) 3D打印技术.
- 评估3D打印植入物的机械性能,药物释放率和表面形态.
主要方法:
- 空洞的圆柱体植入室使用FDM,SLS和MJF3D打印制造.
- 植入物被填充了pentoxifylline,用金膜密封,并接受电刺激以确定释放药物所需的电压.
- 评估了机械电阻,药物泄漏和表面形态.
主要成果:
- 与SLS和MJF相比,沉积建模 (FDM) 3D打印植入物在3个月内表现出更高的精度,机械强度 (Young的模量) 和药物储存能力.
- 扫描电子显微镜 (SEM) 在FDM植入物中发现了最小的孔隙性和良好的层粘附性.
- 一个2毫米金膜需要6V的低电压才能破裂,这使得设计一个紧的电路成为可能.
结论:
- 由于其最小的药物泄漏和有利的机械性能,FDM 3D打印电机植入物被选为最佳设计.
- 这种优化的植入物与小型电路相结合,提供精确的,由医生控制的药物输送能力.
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