在鼻癌辐射后的脑下垂体功能障碍
Nadia Bouzid1, Amal Chamsi1, Ines Barka2
1Medical School Sousse, Radiation Oncology Department, University of Sousse, Farhat Hached Hospital, Sousse, Tunisia.
Clinical neurology and neurosurgery
|January 13, 2024
概括
鼻癌 (NPC) 的放射治疗经常导致幸存者的下丘脑垂体缺陷 (HPD). 男性性别是治疗后发展HPD的重要风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 放射治疗 (RT) 是鼻癌 (NPC) 的首要治疗方法.
- 对于NPC幸存者来说,RT的晚期影响,特别是下丘脑垂体缺陷 (HPD) 是一个重大问题.
- 评估RT对垂体功能的长期影响对于患者管理至关重要.
研究的目的:
- 评估放射治疗后鼻癌幸存者的HPD患病率和特征.
- 为了确定与HPD后RT发展相关的因素.
主要方法:
- 追溯分析了55名NPC患者的队列,这些患者接受了面部部RT治疗.
- 鼻和鼻的平均RT剂量为73.3 Gy.
- 在平均随访9.56年后评估了下垂体功能.
主要成果:
- 61.8%的患者患有高血压.
- 增长激素 (GH) 轴缺陷是最常见的 (50.9%),其次是次要上腺功能不足 (20%).
- HPD的发展不是剂量依赖的,但与男性性别有显著的关联 (OR: 1.67).
结论:
- 脑下垂体缺陷是NPC的RT的常见后果.
- 建议对接受RT治疗的NPC幸存者进行定期的垂体功能评估.
- 早期诊断和激素替代疗法可以改善生活质量.
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