亚托匹性皮肤炎:病理生理学,微生物群和代谢组 - 一个全面的审查
Shahnawaz Mohammad1, Md Rezaul Karim2, Safia Iqbal3
1Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea.
Microbiological research
|January 13, 2024
概括
亚托皮炎 (AD) 与肠道和皮肤细菌失衡有关. 解决微生物组失调症可能有助于管理这种炎症性皮肤疾病.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 亚托皮炎 (AD) 是一种常见的炎症性皮肤疾病,受遗传学,环境和皮肤屏障功能的影响.
- 新兴研究强调了肠道和皮肤微生物群在阿尔茨海默病发展和复发中的重要作用.
- 微生物组失调,其特点是微生物多样性的改变和病原生物的存在,与AD的病原发生有关.
研究的目的:
- 为了回顾阿托皮性皮肤炎的病理生理学.
- 探索肠道和皮肤微生物群与AD之间的联系.
- 讨论代谢学在阿尔茨海默病预防,治疗和管理中的作用.
主要方法:
- 本综述综合了有关亚托皮炎和微生物组的当前科学文献.
- 它检查了肠道和皮肤失生症对表皮屏障完整性和全身炎症的影响.
- 该审查还考虑了微生物代谢物在AD中的作用.
主要成果:
- 肠道失调可以导致"漏肠",允许内毒素进入血液循环并引起炎症.
- 皮肤失生症破坏皮肤平衡,使病原体进入和炎症.
- 微生物群产生的有益和有毒的代谢物都影响AD.
结论:
- 微生物组失调是亚托邦性皮肤炎的一个关键因素.
- 了解肠-皮肤轴和微生物代谢物对于AD管理至关重要.
- 代谢学为AD预防和治疗的新策略提供了潜力.
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