预防感染 - - 我们如何防止社区发病的耐甲基黄金葡萄球菌的传播?
Carol M Kao1, Stephanie A Fritz1
1Department of Pediatrics, Division of Pediatric Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
概括
防止社区发病的抗甲基金色葡萄球菌 (CO-MRSA) 传播需要家庭脱殖和卫生. 疫苗和菌体疗法等新策略正在出现,以对抗复发性感染.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 微生物学 微生物学
背景情况:
- 黄金葡萄球菌,包括耐甲西林菌株 (MRSA),可以是共生性或致病性.
- 社区发病的MRSA (CO-MRSA) 在健康人群中引起侵入性感染和皮肤/软组织感染 (SSTI).
- 黄金菌殖民是感染和传播的危险因素,需要采取预防策略.
研究的目的:
- 为预防CO-MRSA传播提供基于证据的方法.
- 突出家庭和环境中S. aureus殖民性的临床试验.
- 确定预防黄金菌感染的研究优先事项.
主要方法:
- 从同行评审出版物中对初级文献进行叙事审查.
主要成果:
- 皮肤的最佳治疗和卫生教育是关键.
- 对于经常出现的SSTI和家庭接触者,建议进行非殖民化.
- 建议针对所有家庭成员进行针对性的局部抗菌素脱殖.
结论:
- 黄金色杆菌感染导致严重的死亡率和发病率,由于复发性皮肤感染.
- 目前的非殖民化策略是有益的,但成本高昂,效率下降.
- 新的预防策略包括疫苗,菌体治疗和微生物群移植正在开发中.
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