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尿路癌的精密医学:国际视角

Mariane S Fontes¹, Daniel Vargas Pivato de Almeida², Flavio Cárcano³

¹Division of Genitourinary Medical Oncology, Oncoclínicas, Rio de Janeiro, Brazil; LAGOG-Latin American Cooperative Oncology Group, Porto Alegre, Brazil.

Urologic oncology

|January 13, 2024

概括

识别新的生物标志物是改善泌尿器癌治疗的关键. 本综述涵盖了膀癌的有前途的预后和预测标志物,旨在提高患者的选择和结果.

科学领域:

在瘤学瘤学.
翻译研究是翻译研究.

背景情况:

泌尿器癌的治疗得到了新的治疗方法,如化疗,免疫检查点抑制剂,向药物和抗体药物合物.
尽管有进展,但治疗的好处并不普遍,这凸显了需要更好的患者分层.

研究的目的:

对尿道癌的有前途的预后和预测生物标志物进行审查.
为指导临床决策和个性化治疗策略的肌肉侵入性和转移性尿路细胞癌.

主要方法:

关于当前和新兴生物标志物的文献综述.
专注于分子分类器,基因组改变,PD-L1表达,瘤突变负担,ctDNA和尿路生物标志物.

主要成果:

几种生物标志物显示出预测治疗反应和患者结果的潜力.
生物标志物研究对于优化现有和新型泌尿器癌疗法的使用至关重要.

结论:

对这些生物标志物的更深入的理解将有助于在泌尿器癌症中进行个性化医疗.
生物标志物驱动的方法对于改善膀和泌尿器癌的治疗疗效和患者选择至关重要.

关键词:

抗体药物联合体的抗体.膀癌是一种癌症.检查点抑制剂检查点抑制剂免疫治疗是一种免疫疗法.精准医学是一门精准的医学.有针对性的治疗.泌尿器癌症泌尿器癌症是什么

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