一个基于全球人口的综合性分析,以酸性食道炎和炎症性肠病的共存为基础
Alexander Malik1, Benjamin Douglas Liu2, Liangru Zhu3
1Department of Medicine, Summa Health System, Northeast Ohio Medical University, Akron, OH, USA.
Digestive diseases and sciences
|January 13, 2024
概括
患有炎症性肠病 (IBD) 和乙性食道炎 (EoE) 的患者面临IBD并发症的风险较高,但EoE问题较少. 这突出了这些免疫媒介条件之间的复杂相互作用.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 调查炎症性肠病 (IBD) 和eosinophilic oesophagitis (EoE) 的共存对于了解患者的治疗结果至关重要.
- 同时诊断IBD和EoE在临床管理中提出了独特的挑战.
研究的目的:
- 探索与IBD (克罗恩病和性结肠炎) 和EoE共存相关的流行病学和风险.
- 为了增强对患有IBD和EoE同时诊断的个体患者结果的理解.
主要方法:
- 一项以人口为基础的回顾性队列研究,利用TrinetX数据库 (2011-2022) 的非身份化数据.
- 在IBD患者中估计的EoE发生率和流行率,反之亦然.
- 在患有EoE,IBD或两者的患者中,比较免疫介导疾病和疾病并发症的风险.
主要成果:
- 在IBD患者 (CD:PR 11.2;UC:PR 8.7) 中显著增加了EoE风险,在EoE患者 (CD:PR 11.6;UC:PR 9.1) 中显著增加了IBD风险.
- 同时患有EoE和IBD的患者表现出患乳病,IBD相关的炎症状况,湿疹和喘的相对风险增加.
- 同时诊断与较高的IBD相关并发症风险相关 (CD:aHR 1.14;UC:aHR 1.17) 但食物玻尿酸冲击的风险较低 (aHR 0.445).
结论:
- 同时的EoE和IBD诊断增加了IBD相关并发症的风险,需要更密集的治疗.
- 同时诊断可以降低EoE特定问题的发生率,例如食物球体冲击.
- 了解这种并发症对于优化治疗策略和患者护理至关重要.
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