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Updated: Jul 5, 2025

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牙健康和肺癌风险在戈勒斯坦队列研究
Yukiko Yano1, Christian C Abnet2, Gholamreza Roshandel3
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. yukiko.yano@nih.gov.
BMC cancer
|January 13, 2024
概括
牙健康不佳,包括牙脱落和高DMFT分数,与肺癌风险增加和死亡率有关. 然而,经常刷牙与肺癌的结果没有关联.
科学领域:
- 口腔卫生流行病学 口腔卫生流行病学
- 癌症研究 癌症研究
- 公共卫生 公共卫生
背景情况:
- 糟糕的口腔健康是系统性疾病的已知风险因素.
- 之前关于口腔健康和肺癌之间联系的研究得出了不确定的结果.
研究的目的:
- 调查牙状况与肺癌发病率和死亡率之间的关联.
- 检查牙脱落,DMFT和刷牙频率在肺癌风险中的作用.
主要方法:
- 伊朗东北部50 045名成年人的前性队列研究 (戈勒斯坦队列研究).
- 考克斯的比例危险模型被用来评估牙健康措施与肺癌之间的关联.
- 针对吸烟和片使用等混因素进行了调整.
主要成果:
- 较高的DMFT分数和牙损失与肺癌发病率和死亡率的风险逐渐增加有关.
- 失去牙的最高三位数显示肺癌风险显著增加 (HR 1.68).
- 牙刷频率与肺癌结局之间没有发现任何关联.
结论:
- 牙健康不佳,特别是牙脱落和高DMFT,是肺癌的重要风险因素.
- 刷牙的频率似乎没有影响肺癌风险.
- 研究结果强调了口腔健康在预防肺癌的背景下的重要性.
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