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在牙周炎和多发性硬化症之间探索潜在的共享基因特征

Erli Wu¹, Ming Cheng¹, Xinjing Zhang¹

¹College & Hospital of Stomatology, Key Lab. of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, 230032, China.

BMC oral health

|January 13, 2024

概括

这项研究确定了牙周炎和多发性硬化症 (MS) 之间的共享基因,揭示了FAM46C,CFI和DDIT4L作为潜在的诊断生物标志物. 这些发现突出了细菌起源的分子和免疫细胞参与这些条件之间的交叉声.

科学领域:

基因组学和生物信息学
免疫学免疫学免疫学
口腔医学是指口腔医学.

背景情况:

牙周炎和多发性硬化症 (MS) 分享报告的联系,但潜在的分子机制仍然不清楚.
了解牙周炎和MS之间的病理相互作用对于确定共享的疾病途径至关重要.

研究的目的:

探索潜在的交叉基因和牙周炎和多发性硬化症 (MS) 之间的途径.
为了确定两个条件共享的诊断生物标志物.

主要方法:

使用的基因表达综合 (GEO) 数据用于牙周炎和MS.
采用差异表达分析,加权基因共同表达网络分析 (WGCNA) 和LASSO回归来识别共享的基因和生物标志物.
使用实时定量光PCR (qRT-PCR) 和免疫组织化学染色验证了关键基因表达.

主要成果:

他们发现了八个共同的基因:FAM46C,SLC7A7,LY96,CFI,DDIT4L,CD14,C5AR1和IGJ.
丰富分析表明,共享的基因与细菌起源分子有显著的关联.
CFI,DDIT4L和FAM46C被确定为强大的共享诊断生物标志物,并经过实验验证.
单样样本基因组丰富分析 (ssGSEA) 揭示了T细胞和B细胞在MS和牙周炎的发展中起着重要的作用.

结论:

FAM46C,SLC7A7,LY96,CFI,DDIT4L,CD14,C5AR1和IGJ代表了牙周炎和MS之间的关键交叉基因.
CFI,DDIT4L和FAM46C显示为牙周炎和MS的诊断生物标志物具有前途.
这些发现强调了调查口腔健康,细菌感染和MS等神经系统疾病之间的相互作用的重要性.

关键词:

生物标志物生物标志物交叉通话基因的交叉通话基因免疫系统的透.多发性硬化症是多发性硬化症.牙周病是指牙周病的发生.转录组分析转录组分析

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