在抗瘤免疫治疗中纳米材料应用的前沿和热点演变:科学测量分析
Wei Cao1, Mengyao Jin1, Weiguo Zhou1
1Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
Journal of nanobiotechnology
|January 13, 2024
概括
抗瘤纳米免疫疗法将纳米材料与免疫疗法结合起来,以增强瘤消除和免疫记忆. 这个领域正在迅速发展,研究重点是树突细胞,药物输送和瘤微环境.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 瘤免疫疗法提供长期免疫记忆,但面临临临床限制.
- 将纳米材料与免疫疗法结合在一起,为减少副作用的瘤根除提供了一个有希望的方法.
研究的目的:
- 分析抗瘤纳米免疫疗法研究的趋势和关键发展.
- 确定该领域的领先机构,期刊和新兴研究主题.
主要方法:
- 从2004年到2022年使用Web of Science核心集合对443项研究进行了图书统计分析.
- 使用Bibliometrix,VOSviewer,CiteSpace,GraphPad Prism和Excel进行的可视化和统计分析.
主要成果:
- 在出版物方面,每年16.85%的显著增长率.
- 中国和美国在研究成果方面是领先的国家.
- 关键的研究主题包括树突细胞,药物输送,瘤微环境,免疫检查点封锁和光疗法.
结论:
- 抗瘤纳米免疫疗法正在获得显著的关注,并从基本的机制发展到复杂的机制.
- 新兴的研究领域包括树突细胞,疫苗和基于T细胞的疗法.
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:27Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K