在RCC中转移SIRI和SII的预测值:一项前性临床研究
Emre Arı1, Hikmet Köseoğlu2, Tolga Eroğlu1
1Hamidiye Faculty of Medicine, Istanbul Health Practice and Research Center, Department of Urology, Health Sciences University, Istanbul, Turkey.
BMC urology
|January 13, 2024
概括
术前系统性炎症反应指数 (SIRI) 和系统性炎症指数 (SII) 在预测细胞癌 (RCC) 患者的术后转移方面表现出中等效率. 这些血液学标记可能有助于早期检测和治疗计划RCC.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 细胞癌 (RCC) 是一个重要的全球健康问题.
- 在RCC中预测术后转移对于有效的治疗计划至关重要.
- 血液学标记为转移预测提供了一种潜在的非侵入性方法.
研究的目的:
- 评估术前系统性炎症反应指数 (SIRI) 和系统性炎症指数 (SII) 在预测细胞癌 (RCC) 术后转移的效率.
- 为了比较转移性和非转移性RCC患者组之间的SIRI和SII值.
- 在病理诊断之前确定这些标记物的切断值以表明恶性病变.
主要方法:
- 一项前性横截面临床研究包括72名RCC患者.
- 排除标准:二次恶性瘤,血液学/风湿学疾病,最近的输血或最近的感染.
- 根据在活检或手术前获得的全血细胞计 (CBC) 来计算SIRI和SII.
主要成果:
- 与非转移组 (1.26) 相比,转移组 (2.1) 的中位数SIRI值显著更高 (p < 0.05).
- 与非转移组 (566) 相比,转移组 (1434) 的中位数SII值显著更高 (p < 0.001).
- 转移检测曲线下的面积 (AUC) 为SII的0.809和SIRI的0.737.
结论:
- 在RCC中,SIRI和SII在预测术后转移方面表现出中等效率.
- 这些血液学指数可以作为RCC患者转移风险分层的有价值的手术前生物标志物.
- 进一步的研究可以探索它们在指导治疗决策和监测疾病进展中的作用.
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