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性别特定的静止状态大脑网络动态在大型抑郁症患者中

Daifeng Dong^1,2, Diego A Pizzagalli^3,4, Thomas A W Bolton⁵

¹Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

|January 13, 2024

概括

性差异影响严重抑郁症 (MDD) 中的大脑网络活动. 男性MDD患者表现出改变的默认模式网络 (DMN) 和突出网络 (SN) 动态,而两性都表现出DMN主导性和前对对联网络 (FPN) 失活.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经成像是一种神经成像.

背景情况:

大型抑郁症 (MDD) 与关键大脑网络的功能障碍有关,包括默认模式网络 (DMN),突出网络 (SN) 和前端对称网络 (FPN).
越来越多地认识到MDD的性别特异性神经生物学基础,但MDD中性对静止状态网络动态的缓解作用需要进一步研究.

研究的目的:

调查主要抑郁症 (MDD) 对静止状态功能网络动态的性别特异性影响.
确定潜在的神经生物学标记,解释MDD的性别差异.

主要方法:

休息状态功能磁共振成像 (fMRI) 数据从138名未经药物治疗的MDD患者和243名健康对照 (HC) 中获得.
分析了反复出现的功能网络协同激活模式 (CAP),量化了在每个 CAP 中花费的时间,CAP 持久性以及涉及 SN,DMN 和 FPN 的 CAP 之间的过渡.

主要成果:

无论性别如何,MDD患者在DMN激活和FPN关闭 (DMN+FPN-) 的 CAP中表现出更强的持续性.
与男性HC相比,男性MDD患者在DMN-SN相互作用中表现出改变的动态,包括在特定CAP中增加的时间和与DMN相关的CAP之间的更频繁的过渡.
与女性HC相比,女性MDD患者在DMN-SN CAP中表现出较低的持续性.

结论:

SN和DMN之间的相互作用可能代表MDD中的性别特异性神经生物学标志物.
与FPN失活相结合的DMN主导似乎是抑郁症的性别独立的神经相关物.

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