在新生羊模型中,在合规性变化期间,正压通风装置的比较
Kim Hoang Tran1,2, Marwa Ramsie1,2, Brenda Law1,2
1Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, AB, Canada.
Pediatric research
|January 13, 2024
概括
下一步新生儿复苏器在正压通风 (PPV) 过程中始终提供目标的潮体积,在小猪模型中表现优于其他设备. 这种新型设备为新生儿复苏提供了一种安全有效的替代方案.
科学领域:
- 新生儿生理学 新生儿生理学
- 呼吸系统的支持呼吸系统的支持
- 医疗器械创新 医疗器械创新
背景情况:
- 新生儿复苏指南建议固定峰值膨胀压力,可能导致肺和脑损伤.
- 有效的潮体积 (VT) 传递对于新生儿正压通风 (PPV) 至关重要.
- 对比VT传递在不同的PPV设备在不同的肺部合规性至关重要.
研究的目的:
- 为了比较潮体积 (VT) 交付使用四种不同的正压通风 (PPV) 设备在两个肺部合规 (0.5和1.5毫升/厘米H2O).
- 评估下一步新生儿复苏器与新生儿小猪模型中的传统设备的性能.
主要方法:
- 一项随机动物实验研究对10只新生猪 (1-3天大,1.8-2.4公斤) 进行.
- 小猪接受了麻醉,输管和仪器仪表,然后用自膨胀袋 (SIB),T-Piece复苏器,Next Step或法比安呼吸器接受PPV一分钟.
- 通过使用胸部包裹来操纵肺部合规性,并在5毫升/公斤的目标体积下测量VT输送.
主要成果:
- 在符合0.5mL/cmH2O标准时,下一步提供了5.1~0.2mL/kgVT,相当于法比安呼吸器 (4.8~0.5mL/kg).
- 在1.5mL/cmH2O的符合性下,下一步提供5.2(0.6) mL/kgVT,也类似于法比安呼吸器 (4.4(0.7) mL/kg).
- 下一步在实现目标VT交付方面始终超过SIB和T-Piece复苏器.
结论:
- 下一步新生儿复苏器在PPV期间提供一致和有针对性的潮体积传递,与机械呼吸机相当.
- 这种具有成本效益的设备在SIB和T-Pieces上表现出卓越的性能,使其成为新生儿复苏的潜在替代品.
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