在喘表型中,互白素-36的不同表达水平
Jinyan Li1, Zhengda Wang1, Hongna Dong1
1Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
在喘中,特别是中性性喘中,干白素-36α (IL-36α) 和IL-36β (IL-36β) 的含量升高. 这些细胞因子与中性粒细胞数相关,这表明它们在呼吸道炎症和潜在的治疗向中发挥了作用.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 分子生物学分子生物学
背景情况:
- 介素 (IL) -36家族,包括IL-36α,IL-36β,IL-36γ和IL-36Ra,涉及炎症过程.
- IL-36家族在喘病原和其各种表型中的特定作用仍然不完全理解.
研究的目的:
- 为了研究IL-36α,IL-36β,IL-36γ和IL-36Ra在患有轻度喘的患者诱导的唾液中的度.
- 分析这些IL-36异型体与肺功能,其他细胞因子和独特的喘表型之间的关系.
主要方法:
- 诱导液样本从62名轻度控制喘患者和16名健康对照患者中收集.
- 确定炎症细胞数量,并使用ELISA和细胞计数珠阵列测量IL-36家族成员和其他细胞因子的度.
主要成果:
- 与对照组相比,喘患者的IL-36α和IL-36β度显著更高 (分别P=0.003和P=0.031).
- 在喘患者中,IL-36Ra度显著降低 (P<0.001).
- 中性喘在唾液中的IL-36α和IL-36β水平明显高于paucigranulocytic和eosinophilic喘表型. 这些异型与唾液中性粒细胞和总细胞计数呈正相关性.
结论:
- 通过促进中性粒细胞的招募,IL-36α和IL-36β可能会促进喘中的呼吸道炎症.
- 这项研究阐明了中性友性喘的炎症途径,并确定IL-36异型为潜在的治疗点.
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