与抗抑郁药相比,主要抑郁障碍的成年人服用益生菌:系统性审查和网络分析
Shilin Zhao1,2,3, Suisha Liang1,3, Jun Tao4
1Microbiota I-Center (MagIC), Hong Kong Special Administrative Region (SAR), China.
Nutrition reviews
|January 14, 2024
概括
益生菌看起来很有希望作为一种主要抑郁症 (MDD) 的治疗方法,可能为传统抗抑郁药提供替代品. 这一系统性审查发现益生菌是有效的,耐受性良好,在治疗疗效方面排名很高.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 大型抑郁症 (MDD) 治疗面临抗抑郁药的挑战,包括不良影响和社会耻辱.
- 益生菌为MDD提供了潜在的替代或辅助疗法,可能减轻与抗抑郁药有关的问题.
- 在对比性临床试验中存在一个差距,比较MDD的益生菌和抗抑郁药.
研究的目的:
- 进行系统性审查和网络元分析,比较益生菌与抗抑郁药在治疗MDD中的有效性和可接受性.
- 评估针对微生物群的干预措施,包括益生菌,益生菌和共生菌,与已知的抗抑郁药物治疗相比.
- 综合随机对照试验的证据,以告知MDD管理的临床实践.
主要方法:
- 在六个数据库中系统搜索双盲随机对照试验 (2015-2022年).
- 使用抗抑郁药物和针对成人MDD的微生物群的干预措施的安慰剂对照试验的独立选择.
- 在抑郁症症状得分中标准化平均差异 (SMD) 的网络元分析.
主要成果:
- 分析了42项涉及22项干预措施的试验;16项显示在MDD治疗中有效,证据确定性中等至非常低.
- 益生菌在几种抗抑郁药和安慰剂上表现出优越性,在有效性方面仅次于埃斯基塔洛普拉姆.
- 长期使用益生菌 (≥8周) 的耐受性与抗抑郁药可比.
结论:
- 益生菌可以作为一种有效的辅助或独立治疗主要抑郁症 (MDD).
- 研究结果表明,益生菌为传统抗抑郁药提供了可行的替代品,具有可比的长期耐受性.
- 进一步的研究应侧重于直接的对比比较,以巩固益生菌在MDD治疗中的作用.
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