客观化脏超声波回声性和尺寸指标作为儿童功能潜在预测指标
Shrea Goswami1, Rosalia Misseri2, Michelle C Starr1
1Department of Pediatrics, Division of Nephrology, Indiana University, Schwaderer Riley Children's Hospital, 705 Riley Drive, Indianapolis, IN, 46202, USA.
International urology and nephrology
|January 14, 2024
概括
量化的回声性 (EI) 和长度比 (KLR) 可以帮助评估儿童的功能. 较高的EI和KLR与小儿急性损伤和慢性病中较低的估计膜过率 (eGFR) 相相关.
科学领域:
- 儿科脏病学 儿科脏病学
- 医学成像分析 医学成像分析
- 功能评估 功能评估
背景情况:
- 的回声性通常是主观评估,但可能与功能相关联.
- 长也显示了与功能之间的相关性.
- 这项研究旨在量化回声性,并评估其与儿童脏长度和估计膜过率 (eGFR) 的关系.
研究的目的:
- 开发一种可量化的方法来评估的回声性,使用随时可用的软件.
- 评估量化声原性 (EI) 和长度比 (KLR) 与eGFR在患有急性损伤 (AKI) 和慢性病 (CKD) 的儿科患者之间的相关性.
主要方法:
- 进行了一项回顾性观察性研究.
- 声源性指数 (EI) 被计算为右与肝脏平均像素密度的比例.
- 长度比率 (KLR) 通过比较实际和预测长度来确定. 使用相关性分析和ROC分析,EI和KLR都与eGFR相关.
主要成果:
- 该研究包括94名患有AKI,CKD或对照的儿科患者.
- 较高的EI与较低的eGFR相反相关 (r = -0.46,p < 0.0001).
- 在1.0-1.1和1.1-1.2之间的EI预测了EGFR<90和<60毫升/分钟/1.73m2,分别具有良好的AUC值. 此外,KLR还显示了与eGFR的反相关性 (r = -0.25,p = 0.018).
结论:
- 开发了一种可访问的方法来量化脏回声性.
- 在儿童AKI和CKD患者中观察到EI和eGFR之间的反相关性.
- 虽然EI显示出比KLR更强的相关性,但两者都表现为降低EGFR (<60毫升/分钟/1.73米2) 的生物标志物,表现相当好.
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