最近的抗菌碳水化合物制药,药物和输送系统,以克服抗菌素耐药性
Catarina Maria1, Ana M de Matos1, Amélia P Rauter1
1Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Current opinion in chemical biology
|January 14, 2024
概括
抗菌素耐药性是一个日益增长的威胁. 这篇评论强调了最近的基于碳水化合物的抗菌剂和策略,如药物修饰和纳米技术,以对抗耐药细菌.
科学领域:
- 药用化学 医学化学
- 药物发现 药物发现 药物发现
- 碳水化合物化学 碳水化合物化学
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球健康的重大威胁,耐药结核病和其他多抗药性细菌被确定为主要问题.
- 世界卫生组织优先研究和开发具有新型作用机制的新抗菌剂,以应对这一危机.
- 基于碳水化合物的化合物提供治疗优势,并已被探索其抗菌潜力.
研究的目的:
- 总结最近 (2021-2023) 基于碳水化合物的抗菌剂的进展.
- 审查用于开发新型碳水化合物制药和输送系统的各种策略.
- 通过碳水化合物化学来突出打击抗微生物耐药性的关键方法.
主要方法:
- 在2021年至2023年之间发表的研究文献综述.
- 对以碳水化合物为基础的前期药物,药物和输送系统研究的分析.
- 识别流行策略,包括抗生素衍生,纳米技术和药物重新利用.
主要成果:
- 最近的研究重点是开发基于碳水化合物的新型抗菌剂.
- 关键策略包括修改现有的抗生素,使用纳米技术进行药物输送,并重新利用已有的治疗剂.
- 碳水化合物支架正在被用来创造新的药物和有效的输送系统.
结论:
- 基于碳水化合物的方法是开发新抗菌剂的有希望的途径,以对抗日益增长的抗菌素耐药性.
- 现有抗生素的衍生,纳米技术和药物重新利用是这一领域的有效策略.
- 对碳水化合物化学的持续研究对于应对多药耐药性感染的全球挑战至关重要.
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