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在长期暴露在寒冷中,SCD1维持棕色脂肪交感内内和热生成

Zongcai Liu¹, Sijin Zhu¹, Zhiwei Zhao¹

¹Department of Occupational and Environmental Health, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.

Biochemical and biophysical research communications

|January 14, 2024

概括

棕色的脂肪棕色的脂肪

科学领域:

代谢过程中的代谢.
脂肪组织生物学脂肪组织生物学
神经科学是一个神经科学.

背景情况:

棕色脂肪组织 (BAT) 是治疗肥胖和糖尿病的关键目标.
暴露于寒冷会通过交感神经系统激活BAT热生成.
在寒冷适应过程中,BAT和同情网络之间的相互相互作用尚未完全理解.

研究的目的:

研究SCD1介导脂肪酸代谢在BAT热生成和冷暴露期间同情网络重塑中的作用.
阐明BAT热能活动影响交感网络适应的机制.

主要方法:

在长期暴露于寒冷后,在BAT中分析基因表达和脂肪酸概况.
使用缺少Stearoyl-CoA脱酶1 (SCD1) 的小鼠模型.
使用热中性暴露和交感神经切除模型.
研究棕烯酸 (PO) 补充剂的作用.

主要成果:

长期暴露在寒冷中,丰富了SCD1介导的单不和脂肪酸生物合成.
缺少SCD1会影响寒冷适应和BAT热能激活,这取决于交感内置.
缺少SCD1导致了棕酸 (PA) /棕酸 (PO) 比率的失衡.
棕烯酸 (PO) 补充剂挽救了受损的BAT热生成和交感网络可塑性.

结论:

在冷适应过程中,SCD1介导的单不和脂肪酸合成对BAT的热能反应和同情网络适应至关重要.
脂肪酸的平衡,特别是PO,在BAT和交感神经系统之间的交叉声中起着至关重要的作用.
准SCD1和单不和脂肪酸通路为代谢障碍提供了潜在的治疗策略.

关键词:

棕色的脂肪脂肪是什么暴露于寒冷的情况.在SCD1中,SCD1是SCD1.交感性内化是指交感性内化.热生成是一种热生成.

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