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在患有12型脊髓大脑动症的患者中,皮层刺激性异常
Amitabh Bhattacharya1, Albert Stezin1, Nitish Kamble1
1Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Hosur Road, Bangalore, 560029, Karnataka, India.
Parkinsonism & related disorders
|January 14, 2024
概括
脊髓小脑动症12型 (SCA-12) 患者表现出运动皮层刺激性降低和抑制性增加. 经磁刺激 (TMS) 显示RMT,CMCT和cSP与健康对照组相比有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 临床神经生理学 临床神经生理学
背景情况:
- 脊髓小脑动症12型 (SCA-12) 是一种罕见的自体主导性脑动症.
- 它的特点是动作震,肌痛发作,头部震和步态无力.
研究的目的:
- 为了评估SCA-12患者的运动皮层刺激性.
- 使用跨磁刺激 (TMS) 进行评估.
主要方法:
- 参与了9名SCA-12患者和10名健康对照 (HC).
- TMS评估了静止电机值 (RMT),中央电机传导时间 (CMCT) 和反侧静止时间 (cSP).
- 动力衰竭的严重程度是使用动力衰竭评估和评分尺度 (SARA) 来衡量的.
主要成果:
- 与HC相比,SCA-12患者的RMT显著增加,CMCT延长,cSP增加 (p <0.05).
- 患者的平均SARA得分为13.83±3.60.
- 患者的平均年龄为58.11±7.56岁,发病时的平均年龄为51.67±4.18岁.
结论:
- SCA-12患者表现出皮质刺激能力降低.
- 结果表明皮质抑制增加,可能与增强的GABAergic神经递质有关.
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