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头癌的分子亚型 - 临床适用性和与形态特征的相关性

Fabian Stögbauer¹, Raik Otto², Korinna Jöhrens³

¹Technical University of Munich, Germany; TUM School of Medicine and Health, Institute of General and Surgical Pathology, Germany.

|January 14, 2024

概括

一个定制的NanoString面板成功地亚型复发性或转移性头部和部状细胞癌 (R/M-HNSCC). 虽然分子亚型没有影响存活率,但瘤芽已成为不良结果的显著预后因素.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
病理学病理学病理学

背景情况:

复发性或转移性头支状细胞癌 (R/M-HNSCC) 是一个重大的临床挑战.
准确的分子亚型确定对于理解R/M-HNSCC异质性和开发向疗法至关重要.

研究的目的:

评估定制231基因NanoString面板的可行性,用于R/M-HNSCC的分子亚型化.
为了将分子亚型与组织学特征相关联,并评估它们的预后意义.

主要方法:

在FFPE样本上使用231基因NanoString面板进行R/M-HNSCC的分子亚型化.
对H&E染色幻灯片的组织学分析,评估诸如瘤芽,核大小和树突含量等模式.
分子亚型与组织学特征和患者生存结果的相关性.

主要成果:

分子分类将R/M-HNSCC分为基础 (45%),炎症/介质细胞 (30%) 和经典 (25%) 的亚型.
在基底和古典亚型中,安菲瑞古林 (AREG) 表达显著更高,而与介质细胞亚型相比.
没有观察到分子亚型对生存的显著影响;然而,高瘤芽与较差的结果相关.

结论:

231基因的NanoString面板有效用于使用FFPE材料对R/M-HNSCC的分子亚型.
在R/M-HNSCC中瘤芽的预后价值在这个队列中得到证实.
需要进一步的研究来探索分子亚型化对治疗分层化的实用性.

关键词:

疾病复发疾病复发基因表达基因表达头癌是头部和部的癌症.在NanoString中使用.瘤的芽正在发生.

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