在可卡因成的男性中,存在下丘脑-垂体-上腺和上腺功能障碍的证据
Karen D Ersche1,2,3, Jan Stochl1,4, Annette B Brühl1,5
1Department of Psychiatry, University of Cambridge, Cambridge, UK.
European addiction research
|January 14, 2024
概括
可卡因使用会破坏激素调节,导致上腺皮质增生激素 (ACTH) 和皮质醇的变化更大. 可卡因依赖的男性也表现出更高的阴性腺和对阿托莫克赛丁反应的改变.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
背景情况:
- 可卡因使用与荷尔蒙功能障碍有关,包括阴性腺功能障碍,影响生活质量.
- 可卡因的内分泌效应未得到充分报道,并且在成治疗中往往没有得到解决.
- 缺乏意识可能导致只有在紧急情况下才认识到不良影响.
研究的目的:
- 评估可卡因依赖男性的昼间内分泌功能.
- 为了检查可卡因依赖男性对阿托莫克赛丁的反应中的荷尔蒙变化.
- 为了研究潜在的垂体-上腺轴调节障碍.
主要方法:
- 在26名健康男性和27名可卡因依赖男性中评估了白天上腺皮质otrophic激素 (ACTH),皮质醇和.
- 在双盲,安慰剂对照研究中,服用一次40毫克的阿托莫克西丁剂量.
- 在对atomoxetine的反应中检查了激素水平的变化.
主要成果:
- 与对照人群相比,可卡因依赖的男性在白天和阿托莫克赛丁诱导的ACTH和皮质醇反应中表现出更大的变异性.
- 在可卡因依赖的男性中,阿托莫克赛丁导致了过度的ACTH升高,但皮质醇反应减弱.
- 三分之一的可卡因依赖男性表现出不正常的丸激素水平.
结论:
- 研究结果表明,可卡因成个体的脑垂体和上腺反应之间存在潜在的脱节.
- 在可卡因依赖的男性中观察到更高的阴性腺的患病率.
- 需要对可卡因的内分泌作用和临床影响进行进一步的研究.
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