口腔链球菌与原结合蛋白的突变菌是内动脉瘤破裂或形成的危险因素吗?
Hirokazu Nakatogawa1, Kazuya Hokamura2, Ryota Nomura3
1Department of Neurosurgery, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Cerebrovascular diseases (Basel, Switzerland)
|January 14, 2024
概括
阳性Cnm的Streptococcus mutans (CP-SM) 与破裂的内动脉瘤 (IAs) 没有联系. 然而,CP-SM可能参与较小,易受伤害的动脉瘤的发展,这表明它可能在IA形成中发挥作用.
科学领域:
- 口腔微生物学 口腔微生物学
- 血管病理学 血管病理学
- 传染性疾病传染性疾病.
背景情况:
- 突变性菌株 (Streptococcus mutans,SM) 具有一种与出血性血管疾病相关的原结合蛋白Cnm.
- 在Cnm阳性SM (CP-SM) 和内动脉瘤 (IA) 破裂之间的关联还不清楚.
研究的目的:
- 调查CP-SM与内动脉瘤破裂之间的关系.
主要方法:
- 一项多中心研究在2013年5月至2018年6月期间从431名破裂IA (RIA) 患者和470名未破裂IA (UIA) 患者收集唾液样本.
- 收集了患者人口统计,生活方式因素和动脉瘤特征的数据.
主要成果:
- 在RIA (17.2%) 和UIA (19.4%) 的患者之间没有观察到CP-SM阳性率的显著差异.
- 分分析显示,与≥10毫米 (p = 0.0304) 相比,IA<5毫米的CP-SM阳性率高于IA<10毫米的CP-SM阳性率.
- 总的来说,CP-SM阳性与动脉瘤大小相反相关 (p = 0.0393).
结论:
- CP-SM与内动脉瘤破裂无关.
- 研究结果表明,CP-SM在形成较小,易受伤害的动脉瘤方面可能发挥作用.
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