糟糕的牙健康是气膜脊恶性瘤的危险因素
Katherine W Chang1, Angela L Mazul1, Daniel P Lander1
1Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
概括
严重的牙损失表明牙健康状况不佳,这与患有膜脊癌的风险显著增加有关. 即使考虑到吸烟和饮酒等因素,这种关联仍然存在.
科学领域:
- 口腔瘤学 在口腔瘤学
- 牙科流行病学 牙科流行病学
背景情况:
- 牙健康不佳是一个普遍的问题,可能会对全身健康产生影响.
- 牙状况与口腔状细胞癌 (OCSCC) 亚部位之间的特定关联需要进一步调查.
研究的目的:
- 调查牙健康状况不佳,以缺失牙的数量量化,与OCSCC风险之间的关系.
- 为了检查口腔内的不同瘤亚部位之间的这种关联.
主要方法:
- 进行了一项病例控制研究 (卡罗莱纳头癌流行病学研究 (CHANCE)) 和一个横截面分析 (WashU/Siteman队列).
- 较差的牙健康被评估为缺失的牙数量 (0-6, 7-24, 25-28).
- 使用后勤回归模型计算调整的赔率比率 (aOR).
主要成果:
- 在CHANCE研究中,几乎完全失去牙 (25-28颗缺失的牙) 与膜脊恶性瘤的风险增加3.5倍有关.
- 这一发现得到了华盛顿大学/西特曼研究的证实,该研究显示,与25-28颗牙缺失的个体的舌头癌症相比,膜脊癌的风险增加了4.6倍.
结论:
- 牙健康不佳与膜脊癌的风险增加有关,这与吸烟和酒精等主要风险因素无关.
- 进一步的前性和翻译性研究是有必要的,以证实这些发现,并了解潜在的机制.
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