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视网膜母细胞瘤眼睛视网膜色素上皮的化疗后变化

Dipankar Das¹, Obaidur Rehman², Kasturi Bhattacharjee²

¹Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

|January 14, 2024

概括

在视网膜母细胞瘤 (RB) 病例中,全身化疗会导致特征性的组织病理性视网膜色素上皮质 (RPE) 变化. 这些RPE变化很可能是由于化疗诱导的细胞核损伤.

科学领域:

眼科医生眼科眼科
在瘤学瘤学.
组织病理学组织病理学

背景情况:

视网母细胞瘤 (RB) 是儿童常见的眼内恶性瘤.
手术前的化疗是RB的标准治疗方式.
了解与治疗相关的组织病理变化对于患者管理至关重要.

研究的目的:

分析视网膜母细胞瘤 (RB) 患者的视网膜色素表皮 (RPE) 在化疗后发生的组织病理变化.
为了将观察到的RPE变化与全身化疗治疗相关联.

主要方法:

对51例视网膜母细胞瘤病例进行了回顾性观察研究.
分析了经过化疗后核化疗的17例病例.
使用光素和血素和欧染料对RPE进行组织病理学检查.

主要成果:

在100%的化疗后核化RB眼中观察到中央RPE细胞核的变化.
焦点和扩散的RPE变化发生在5.88%的病例中.
此外,还发现了多 (47.06%) 和RPE扩散 (17.65%).

结论:

系统化疗在视网膜母细胞瘤患者的RPE中诱导了特征性的组织病理变化.
这些RPE变化很可能是化疗引起的细胞核损伤的结果.

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