通过降低BP目标 (PCOT) 预防认知衰退:一个随机的,务实的,多健康系统临床试验
John M Giacona1, Brooke M Bates2, Venkatraghavan Sundaram3
1Hypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, USA; Department of Applied Clinical Research, School of Health Professions, University of Texas Southwestern Medical Center, USA.
Contemporary clinical trials
|January 14, 2024
概括
这项研究调查了降低血压 (BP) 到<130/80 mmHg是否可以安全地减缓患有高血压的老年人认知能力下降. 通过降低血压预防认知衰退的目标试验 (PCOT) 将密集的血压降低与常规护理进行比较.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 强化降低血压可以预防轻度认知障碍 (MCI) 和痴呆症.
- 由于安全问题,目前的指导方针缺乏针对老年人的一致的BP目标.
- 该PCOT试验解决了关于安全的BP目标的证据需求,以防止认知衰退.
研究的目的:
- 为了确定一个实施的战略,降低心压<130 mmHg和心压<80 mmHg,安全地减缓高血压的老年人认知衰退.
- 为了比较密集降低血压与常规护理在预防认知衰退方面的有效性.
- 评估强化降血压在老年人群中降血压的安全性.
主要方法:
- PCOT试验是一个随机的实用临床试验,涉及4000名70岁以上的患者,血压>130/80 mmHg.
- 参与者被随机分配到干预组 (以团队为基础的护理,为BP<130/80 mmHg提供决策支持) 或通常的护理.
- 主要结果是通过修改的认知状态 (TICS-m) 电话访谈得分的变化来衡量认知衰退.
主要成果:
- 这个部分不在所提供的摘要中.
结论:
- 该PCOT试验将评估高血压治疗的有效性和安全性,在现实环境中以较低的BP目标治疗高血压.
- 研究结果将为临床实践提供有关老年人认知健康的BP管理的信息.
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