诺基普拉斯疼痛和疼痛驱动的饮酒在酒精使用障碍中
Orman Trent Hall1, Johnathan Rausch1, Parker Entrup1
1Department of Psychiatry & Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
The journal of pain
|January 14, 2024
概括
鼻膜性疼痛是一种放大疼痛信号,与饮酒以缓解酒精使用障碍 (AUD) 患者的疼痛有独特的联系. 一个新的量表,疼痛动机饮酒量表 (PMDS),证实了这一关联.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 疼痛研究 疼痛研究
背景情况:
- 严重的慢性酒精使用可以通过神经化学和神经可塑性变化放大疼痛.
- 诺基普拉斯痛,以放大疼痛信号为特征,与酒精使用障碍 (AUD) 中观察到的变化有相似之处.
- 现有的研究缺乏研究,这些研究将nociplastic疼痛与AUD中的疼痛动机饮酒行为联系起来.
研究的目的:
- 为了调查AUD患者的nociplastic疼痛和疼痛驱动的饮酒之间的联系.
- 开发和验证一个新的尺度,疼痛动机饮酒量表 (PMDS),用于测量疼痛动机饮酒.
- 评估PMDS的心理测量特性,包括其因子结构,可靠性和有效性.
主要方法:
- 一项横截面的观察性研究招募了138名来自学术成治疗设施的AUD参与者.
- 新开发的疼痛动机饮酒量表 (PMDS) 用于测量疼痛动机饮酒.
- 评估了nociplastic疼痛,并使用多重层次线性回归来分析与PMDS得分的关联,控制混因素和疼痛严重程度.
主要成果:
- 超过72%的参与者报告说,至少有时会喝酒来缓解疼痛.
- 超过42%的人报告说,疼痛缓解至少在一半的时间里激励了他们的饮酒.
- 在控制疼痛严重程度和其他潜在混因素后,诺西普拉斯疼痛与疼痛驱动的饮酒 (PMDS分数) 有显著的关联.
结论:
- 在患有酒精使用障碍 (AUD) 的个体中,诺西普拉斯疼痛与疼痛驱动的饮酒独立相关.
- 疼痛动机饮酒量表 (PMDS) 显示出有希望的心理测量特性,用于测量疼痛动机饮酒.
- 这些发现突出了在nociplastic疼痛机制和动机喝酒来缓解AUD的疼痛之间的独特联系.
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