怀孕期间的城市环境和学龄儿童的肺功能,喘息和喘. 这一研究是关于R世代的研究
Alicia Abellan1, Charline Warembourg2, Sara M Mensink-Bout3
1The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
怀孕期间暴露于城市环境会影响儿童的呼吸系统健康. 较高的空气污染和噪音,以及较少的绿色空间,与肺功能不佳和儿童呼吸喘增加有关.
科学领域:
- 环境流行病学环境流行病学
- 儿科呼吸系统健康 儿科呼吸系统健康
- 城市暴露组研究
背景情况:
- 怀孕期间的城市环境被怀疑会影响后代的呼吸健康.
- 有限的研究系统地评估了多次城市暴露对儿童肺功能和喘的影响.
- 了解这些关联对于城市环境中的公共卫生干预至关重要.
研究的目的:
- 调查产前城市环境与儿童呼吸道结果之间的关联.
- 评估对肺功能,学龄前喘息和学龄喘的影响.
- 确定特定的城市暴露模式,与后代的不良呼吸系统健康有关.
主要方法:
- 利用了来自5624个母婴对在预期出生队列中的数据.
- 在怀孕期间评估了30种城市暴露 (空气污染,噪音,绿色空间,建筑环境).
- 采用暴露全组关联研究 (EWAS) 和具有多变量回归的层次聚类.
主要成果:
- 较高的颗粒物暴露 (PM2.5) 与中部呼气流量减少 (FEF25-75%) 和FEV1/FVC增加有关.
- 高空气污染,噪音,可行性和低自然空间的集群,与较低的FEF25-75%和更高的学前喘有关.
- 怀孕期间特定的城市环境模式显著影响后代的呼吸系统健康结果.
结论:
- 产前城市环境对儿童的呼吸健康起着重要作用.
- 暴露于不利的城市环境,特别是空气污染和噪音,可能会对肺部发育产生负面影响,并增加呼吸道症状.
- 调查结果强调需要城市规划策略,以促进孕妇及其孩子的健康环境.
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