来自Anadenanthera colubrina的碳氧甲基的胃保护活性和物理化学分析

相关实验视频

Updated: Jul 5, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.3K

Letícia S Chaves¹, Antonio C P Oliveira¹, Samara S Pinho¹

¹Laboratory of Inflammation and Translational Gastroenterology (LIGAT), Postgraduate Program in Biotechnology (PPGBIOTEC), Federal University of Delta do Parnaíba, Av. São Sebastião, 2819, Parnaíba, PI CEP 64202-020, Brazil.

International journal of biological macromolecules

|January 14, 2024

概括

红色牙 (AG) 被改为碳甲基化牙 (CAG),以创建一种新型的胃保护剂. CAG与胃粘膜的相互作用增强,对乙醇诱导的有显著的保护.

科学领域:

生物技术是生物技术.
聚合物化学聚合物化学
药理学药理学是指药理学的学科.

背景情况:

胃的有效治疗需要具有增强生物效能的分子.
多电解质化合物提供了改善药物递送和与生物组织相互作用的潜力.
天然是一种用于生物技术应用的生物相容聚合物的来源.

研究的目的:

为了从红色血管 (AG) 中合成和表征碳素甲基化血管 (CAG).
评估AG和CAG的物理化学特性.
在体内和体外研究AG和CAG对乙醇诱导的胃的胃保护作用.

主要方法:

红色牙 (AG) 经过碳甲基化进行了修改,以产生CAG.
使用富里叶变换红外光谱学,13C NMR,凝透色谱 (GPC) 和替代度的确定进行物理化学表征.
通过评估宏观和微观损伤,抗氧化活性 (体外),以及超氧化物失调酶,谷氨,甲和亚酸盐 (体内) 的水平来评估胃保护.
原子力显微镜被用来分析在酸性pH的粘膜相互作用.

主要成果:

碳氧甲基化成功修改了血管,改变了它的形状,增强了粘膜相互作用.
AG和CAG都显著减少了乙醇诱导的胃损伤,包括,出血和细胞损失.
对两种牙观察到体外抗氧化活性.
在体内,CAG预处理恢复了抗氧化酶水平 (超氧化脱酶,谷氨) 并降低了氧化应激标志物 (甲,酸盐).
原子力显微镜表明,在酸性pH下,CAG比AG对胃粘膜具有更高的亲和力和保护性.

结论:

碳甲基化是一种有效的方法,可以增强安吉科口香糖的胃保护性质.
CAG表现出显著的抗氧化和细胞保护作用,使其成为治疗胃的有希望的候选人.
在酸性pH下,CAG与胃粘膜的改善相互作用突出了其在胃肠道疗法中的生物技术应用潜力.

关键词:

化学修饰是一种化学修饰.胃损伤胃损伤胃损伤多糖是一种多糖化合物.

相关概念视频

01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

176

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...

176

01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

218

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...

218