在中度至重度性结肠炎中使用vedolizumab诱导过程中选择性颗粒细胞 - 单细胞:在三级医院的经验
Cristina Suárez Ferrer1, Eduardo Martin-Arranz1, María Dolores Martín-Arranz2
1Instituto de Investigación Sanitaria Hospital Universitario La Paz-IdiPAZ, Madrid, Spain; Servicio Aparato Digestivo, Hospital Universitario La Paz, Madrid, Spain.
概括
结合维多利祖马布 (VDZ) 的颗粒细胞和单细胞非雷斯 (GMA) 对性结肠炎 (UC) 患者显示出有前途. 这种治疗在大多数患者中实现了临床缓解,没有观察到严重的不良事件.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 医疗技术 医疗技术 医学技术
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 中度至重度的UC通常需要先进的治疗.
- 维多利祖马布 (VDZ) 是一种已确立的UC生物药物,但有些患者表现出不完全的反应.
研究的目的:
- 为了评估结合颗粒细胞和单细胞非雷斯 (GMA) 与vedolizumab (VDZ) 进行诱导治疗的疗效和安全性.
- 为了评估中度至重度UC患者对类固醇反应不完全的患者的结果.
- 分析临床,生化和内镜反应,以及切除术率和不良事件.
主要方法:
- 在诱导期间接受GMA + VDZ的6名UC患者的回顾性审查.
- 这些患者之前的反TNF治疗都失败了.
- 收集的数据包括疾病特征,治疗史,临床反应 (缓解,没有缓解的反应,没有反应),生化标志物 (calprotectin,CRP),内镜发现和不良事件.
主要成果:
- 在6名患者中,有4名患者实现了临床缓解,并保持了深度缓解.
- 随访时间中位数为57.6个月.
- 没有观察到calprotectin或CRP的显著下降,但没有患者需要进行小肠切除术.
- 没有报告与治疗相关的不良事件.
结论:
- 在诱导疗法期间将GMA与VDZ结合起来,似乎是选择UC患者的有效和安全的策略.
- 这种方法可能对中度至重度UC和部分类固醇反应的患者有益.
- 需要对更大的队列进行进一步的研究来证实这些发现.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
142
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
142
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
120
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
120
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
166
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
166


