猪肠体是病毒性基因的重要储存和转移载体
Yalu Ji1, Hengyu Xi1, Chong Chen1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
The Science of the total environment
|January 14, 2024
概括
猪肠病毒,菌体,携带病毒性基因,可以增加疾病风险. 腹加剧了这种情况,引发了人们对肠道微生物群中菌体介导的基因转移的担忧.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 动物科学动物科学
背景情况:
- 菌体 (菌体) 是动物肠道病毒体的关键组成部分,可以转移毒性基因,影响宿主致病性.
- 关于小猪肠菌组及其在携带毒性基因中的作用的研究有限.
研究的目的:
- 为了在断奶小猪的肠道菌群中识别毒性基因.
- 研究菌体编码的毒性基因,移动基因元素 (MGE) 和宿主健康状况 (腹) 之间的相关性.
主要方法:
- 来自断奶小猪的肠道菌素序列的生物信息分析.
- 在菌体内识别和量化毒性基因和MGE基因.
- 基因丰富度与宿主健康之间的相关性分析.
主要成果:
- 在小猪肠菌体中发现了185个毒性基因,其中0.688%的菌体结合体编码至少一个毒性基因.
- 该pblA基因是最丰富的毒性基因;多个毒性和MGE基因被发现位于单个菌体序列上.
- 腹与携带毒性和MGE基因的菌体数量增加有关.
结论:
- 猪肠菌体含有大量的毒性基因,构成横向基因转移的潜在风险.
- 病毒性和MGE基因在菌体上同时发生,增加了菌体介导病原发生的风险.
- 了解小猪肠病菌组对于管理动物健康和预防疾病传播至关重要.
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