怀孕期间晚上暴露于室外人工光和葡萄糖平衡之间的关联:一项前性队列研究
Lei Zhang1, Haixia Wang1, Ping Zu1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei, China.
在怀孕早期暴露于夜间室外人工光线 (ALAN) 与较差的葡萄糖控制有关. 这项研究表明,管理光污染对孕产妇健康至关重要.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 代谢健康 代谢健康
背景情况:
- 夜间人工照明 (ALAN) 是一个日益严重的环境问题.
- 现有的研究将ALAN与糖尿病风险联系起来,但它对妊娠葡萄糖平衡的影响还未得到充分研究.
研究的目的:
- 调查在怀孕期间户外ALAN暴露和葡萄糖平衡之间的关联.
- 评估ALAN与妊娠期糖尿病 (GDM) 风险之间的关系.
主要方法:
- 一项前性队列研究,涉及中国合肥6730名孕妇.
- 室外ALAN曝光量化使用1公里分辨率的卫星数据.
- 妊娠期糖尿病 (GDM) 通过使用标准口服葡萄糖耐受性测试来诊断;统计模型估计了ALAN对葡萄糖和胰岛素水平的影响.
主要成果:
- 在头三个月内,更高的户外ALAN强度与高的空腹血葡萄糖,胰岛素水平和HOMA-IR相关.
- 在ALAN和整体GDM风险之间没有发现显著的关联.
- 在夏季和秋季怀孕的女性中,这种关联更强烈.
结论:
- 怀孕早期更明亮的户外ALAN与葡萄糖不耐受性损害有关.
- 这些影响在温暖的季节怀孕的女性中尤其明显.
- 建议制定减轻光污染的策略,以保护母亲的健康和预防妊娠并发症.
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