桑提取物和净化分量的抗菌活性对抗口腔致病细菌
Takahisa Shirai1, Yutaroh Satoh2, Kazuyuki Ishihara3
1Faculty of Dentistry, Ohu University, 31-1 Misumido, Tomita-cho, Koriyama-city, Fukusima, Japan.
Journal of oral biosciences
|January 14, 2024
概括
树叶中含有抗菌化合物,可以有效地对抗牙周病的细菌,如 Porphyromonas gingivalis. 这些天然化合物显示出治疗牙疾病的巨大潜力.
科学领域:
- 植物化学 植物化学
- 微生物学 微生物学
- 牙周病学 牙周病学
背景情况:
- 牙周病细菌是导致牙疾病的关键因素.
- 自然产品越来越多地被探索其抗微生物特性.
研究的目的:
- 为了隔离和识别木 (Morus alba) 叶子中的抗菌化合物.
- 为了评估这些化合物的有效性对关键的牙周病变细菌.
主要方法:
- 使用乙提取木叶组成部分.
- 通过凝开放列染色学净化提取物.
- 确定针对 Porphyromonas gingivalis 和其他口腔细菌的最小抑制度 (MIC).
主要成果:
- 原始提取物显示出对P. gingivalis的抑制活性 (MIC: 62.5-125 μg/mL).
- 纯化分数CfK和CfP对P. gingivalis,Fusobacterium nucleatum,Prevotella intermedia和Streptococcus mutans.表现出强烈的活性.
- 分数CfK表现出特别强烈的活性,MIC低至6.25μg/mL,对抗P. gingivalis.
结论:
- 树叶含有强大的抗菌化合物.
- 这些化合物对主要的牙周病变细菌有效,包括P. gingivalis,F. nucleatum和P. intermedia.
- 树叶提取物是开发治疗牙周病的有希望的天然来源.
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