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在终身抑郁症中对恐惧的面孔的反应中破坏了边缘-前额有效的连接

Aleks Stolicyn¹, Mathew A Harris¹, Laura de Nooij²

¹Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom.

Journal of affective disorders

|January 14, 2024

概括

重度抑郁症 (MDD) 与杏仁体和背侧前额皮层 (DLPFC) 活动增加以及在看到恐惧面孔时更强的杏仁体-DLPFC抑制有关. 这些发现澄清了抑郁症中大脑连接中断的原因.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
脑部成像脑部成像

背景情况:

之前关于主要抑郁症 (MDD) 和负面情绪偏见的研究已经产生了不一致的结果.
不一致性可能源于样本大小小,以及关于观察到的大脑变化是否具有当前或过去抑郁症的特征的缺乏清晰度.
MDD对桃体和前额叶皮层之间的有效连接的影响尚不清楚.

研究的目的:

在大量人口样本中调查大脑激活和有效的连接,以应对恐惧的面部表情.
确定是否有重大抑郁障碍 (LMDD) 的终身病史与桃体和背侧前额皮层 (DLPFC) 功能和连接性发生变化有关.
为了澄清LMDD和大脑对负面情绪刺激的反应之间的关系.

主要方法:

使用功能磁共振成像 (fMRI) 对一个基于人口的大型样本 (苏格兰一代).
比较MDD (LMDD) 史和没有MDD的个体之间的大脑激活和有效连接.
使用隐式面部情绪处理任务,涉及中立和恐惧的面孔.

主要成果:

患有LMDD的个体表现出左桃体增加和左DLPFC激活,以应对恐惧的面孔.
在LMDD中观察到平均双边杏仁体激活的显著增加.
在LMDD中发现左桃体与左DLPFC之间较强的抑制连接,独立于抑郁症严重程度或药物状态.

结论:

终身严重抑郁症 (LMDD) 与杏仁体和DLPFC的过度活跃有关.
在对恐惧刺激的反应中,从杏仁体到DLPFC的增强抑制连接与LMDD有关.
这些发现表明,在有抑郁病史的人群中",自下而上"的边缘 - 前额有效连接受到干扰.

关键词:

阿米格达拉的一个桃体.有效的连接性有效的连接性恐惧的面孔,可怕的面孔.功能性核磁共振成像 (MRI) 是一种功能性核磁共振成像.大型抑郁症主要是抑郁症.前额叶皮层前额叶皮层.

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