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基于富可伊丹的双重向微囊,用于动脉血栓溶解和再封闭抑制

Zhechang Chen¹, Caijie Yuan¹, Yaxin Ye¹

¹State Key Laboratory of Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China.

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概括

一种新的双向药物递送系统,使用奇托桑和富科伊丹,显示了增强的动脉血栓治疗. 这个系统在需要时准确地释放尿激酶类型的血原激活剂 (uPA),改善血栓溶解并防止重新封闭.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
心血管研究研究心血管研究

背景情况:

动脉血栓形成是一个主要的健康威胁,目标治疗选择有限.
目前的治疗方法缺乏精确的药物输送和受控释放机制.

研究的目的:

开发一种双重向,双重响应的药物输送系统,用于动脉血栓形成.
为了提高泌尿酸酶类型等离子素激活剂 (uPA) 交付的疗效.

主要方法:

基托 (CS) 和富可伊丹 (Fu) 载体的层层组装.
用cRGD进行表面修饰,用于双重向 (P-选择素和αIIbβ3).
封装uPA和评价pH值和血小板响应释放.

主要成果:

在模拟的动脉剪切率下,uPA-CS/Fu@cRGD系统表现出卓越的准效率.
在小鼠模型中有效的血栓溶解和凝血/炎症因子的下调.
改善了血栓微环境和预防重新封闭的潜力.

结论:

基于富可伊丹的巨型片为血栓形成的先进药物输送提供了一个有前途的平台.
双重向和双重响应特性提高治疗结果.
有可能减少凝血,改善血栓溶解,并防止重新封闭.

关键词:

抗血小板细胞聚合.动脉血栓形成的原因是动脉血栓.双重准可以实现.福科伊丹是一个子.抑制重新封闭的抑制.

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