血尿素与急性缺血性中风的3个月结果有非线性关联:基于前性队列研究的第二次分析
Pan Zhou1, Ren-Li Liu1, Fang-Xi Wang1
1Department of Emergency Medicine, Shenzhen Second People's Hospital / the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China.
Clinical nutrition ESPEN
|January 14, 2024
概括
血液尿素 (BUN) 水平显示,在急性缺血性中风 (AIS) 患者中,与不良结果的非线性关联. 维持BUN在13mg/dl左右可能会降低AIS患者3个月不良结果的风险.
科学领域:
- 神经学 神经学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床医学 临床医学
背景情况:
- 关于血液尿素 (BUN) 与急性缺血性中风 (AIS) 患者的3个月结局之间的联系的证据有限.
- 这项研究调查了AIS后3个月的BUN水平和不良结果之间的关系.
研究的目的:
- 探索BUN水平与被诊断患有AIS的患者3个月不良结果的风险之间的联系.
- 为了确定这种协会中的潜在门或模式.
主要方法:
- 追溯研究包括从2010年1月到2016年12月的1866名AIS患者.
- 分析采用了二进制物流回归,平滑曲线拟合和灵敏度分析.
- 研究了BUN和3个月的不良结果之间的关联.
主要成果:
- 在AIS患者中观察到BUN和3个月的不良结果之间存在非线性关系.
- 在13 mg/dl时,确定了BUN的拐点.
- 在13 mg/dl以下,BUN的每个单位增加都与14.1%的不良结果风险降低有关 (OR=0.859,p=0.0019). 在这一点以上,这种关联在统计学上并不显著.
结论:
- 在AIS患者中,BUN水平和3个月的不良结果之间存在非线性,和的关系.
- 维持BUN水平在13 mg/dl左右可能有助于降低AIS后不良结果的风险.
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