贝叶斯诊断测试评估和胃癌患者营养不良的真实流行率估计
Xite Zheng1, Xiaoli Ruan1, Xiaonan Wang1
1Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, 100069, China.
Clinical nutrition ESPEN
|January 14, 2024
概括
患者生成主观全球评估 (PG-SGA) 是诊断胃癌 (GC) 患者营养不良的最可靠方法. 2002年营养风险查 (NRS-2002) 适合进行查,而全球营养不良领导倡议 (GLIM) 标准可能需要进行评估.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 胃癌 (GC) 患者的营养不良很常见,影响结果.
- 早期营养评估对于指导干预至关重要.
- 这项研究评估了GC患者的营养工具.
研究的目的:
- 评估三种营养工具在GC患者中的准确性和预后能力.
- 为营养评估的临床实施提供见解.
- 在GC中确定最佳的营养不良诊断和查工具.
主要方法:
- 分析了1308名成年GC患者的数据 (多中心,2013年7月至2018年7月).
- 使用NRS-2002,PG-SGA和GLIM标准评估营养状况.
- 贝叶斯潜伏类模型 (LCM) 用于流行,敏感性和特异性; 考克斯回归用于预后分析.
主要成果:
- 在NRS-2002,PG-SGA和GLIM分别发现了50.46%,76.76%和68.81%的营养不良.
- PG-SGA显示了最高的灵敏度 (0.96),其次是GLIM (0.78) 和NRS-2002 (0.65).
- 营养不良状态独立预测了整体存活率 (OS) 和改善了TNM分期系统预测.
结论:
- PG-SGA是诊断GC患者营养不良的最可靠工具.
- NRS-2002适用于临床实践中的查;由于NRS-2002的敏感性较低,可能需要GLIM进行评估.
- 具体的行动应该与每个工具联系在一起,这需要进一步的研究.
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