在类风湿性疾病中补充辅酶Q10:系统性审查
Jozélio Freire de Carvalho1, Thelma Skare2
1Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis (NUPEN), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.
辅酶Q10 (CoQ10) 是一种有前途的辅助疗法,用于治疗类风湿性疾病,如类风湿性关节炎和纤维肌痛. 补充改善了患者的症状和炎症标志物,具有良好的耐受性.
科学领域:
- 类风湿病学 类风湿病学
- 营养科学 营养科学
- 生物化学 生化学
背景情况:
- 辅酶Q10 (CoQ10) 是一种内源性抗氧化剂,具有抗炎性质.
- 它在类风湿性疾病中的治疗潜力仍然是积极研究的领域.
研究的目的:
- 系统地审查有关辅酶Q10补充剂在治疗各种类风湿性疾病中的有效性现有的文献.
- 综合有关CoQ10对疾病活动,生物标志物和患者报告结果的影响的发现.
主要方法:
- 在PubMed/Medline,Embase,Scopus和Web of Science数据库中进行了全面的文献搜索.
- 包括从1966年到2023年4月发表的专注于CoQ10和类风湿性疾病的文章.
- 分析了20项涉及483名患者的研究的数据.
主要成果:
- 在类风湿性关节炎 (RA) 患者中补充CoQ10导致疾病活性改善,炎症标志物 (ESR) 减少,细胞因子水平降低,氧化压力 (甲) 降低.
- 在抗脂综合征 (APS) 中,CoQ10增强了内皮功能,并减少了前血栓和前炎性介质.
- 纤维肌痛 (FM) 患者在疼痛,疲劳,睡眠质量,敏感点,情绪和FIQ分数方面经历了显著改善.
结论:
- 辅酶Q10显示出作为一种有效的类风湿性关节炎和纤维肌痛辅助疗法的潜力.
- 该物质通常耐受良好,报告的副作用最小.
- 需要对更大的队列和各种类风湿性疾病进行进一步的研究来证实这些发现.
更多相关视频
04:50Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
07:44Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
Published on: July 14, 2023
相关概念视频
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
