在基托/PEO-PPO-PEO块共聚合物矩阵中的切莱可西布-基基基基基基基基:结构效应和药物释放
Valentino Laquintana1, Angela A Lopedota1, Marianna Ivone1
1Department of Pharmacy, Pharmaceutical Sciences, University of Bari Aldo Moro, Orabona 4, 70126 Bari, Italy.
Journal of colloid and interface science
|January 14, 2024
概括
这项研究表明,2-基-β-环德素 (HP-β-CD) 抑制了Poloxamer 407和奇托混合物中的凝形成. 酸诱导了叶片相,而奇托形成了六角相,影响着赛莱可西布的释放.
科学领域:
- 聚合物科学和材料科学
- 药物输送系统是药物输送系统.
- 生物材料工程是生物材料的工程.
背景情况:
- 波洛克萨默407 (P407) 和Pluronic® F127是FDA批准的triblock共聚合物,广泛用于药物输送.
- 2-propyl-β-cyclodextrin (HP-β-CD) 是一种常见的辅助剂,用于增强药物的溶解性和稳定性.
- 奇托是一种生物相容的多糖,在药物输送中具有潜在的应用.
研究的目的:
- 为了研究16%重量%P407和奇托混合物的气质和结构性质.
- 为了评估将2-基-β-环德素 (HP-β-CD) 和一个celecoxib-HP-β-CD纳入复合物纳入混合物的影响.
- 了解乙酸和酸对系统相位行为和药物释放的影响.
主要方法:
- 风学测量以评估流量和粘弹性质.
- 微角X射线散射 (SAXS) 用于确定结构相位.
- 动态光散射 (DLS) 用于粒子大小分析.
- 实验室药物释放研究,以监测赛莱科克西布释放动力学.
主要成果:
- 添加HP-β-CD抑制了P407和奇托混合物中的凝形成.
- 与P407和单独的奇托相比,塞莱科西布-HP-β-CD纳入复合物没有显著改变混合物的结构.
- 酸诱导了叶片相,改善了可注射性.
- 乙酸中的奇托导致六边形阶段,影响着赛莱可西布的释放.
结论:
- 这项研究阐明了P407和酸盐混合物在不同条件下的复杂相位行为.
- 这些发现表明,可以使用乙酸和奇托来调整质和结构性质,以优化药物输送.
- 在这种特定的混合系统中,HP-β-CD对凝的影响需要进一步研究.
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