心脏代谢风险评估:一项针对巴西青少年的学校研究
Ribanna Aparecida Marques Braga1, Ilana Nogueira Bezerra2, Maria Dinara de Araújo Nogueira3
1Postgraduate Program in Nutrition and Health, State University of Ceará, Fortaleza, Brazil.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|January 14, 2024
概括
内脏脂肪指数 (VAI) 和高度校正的脂质积累产物 (HLAP) 有效预测青少年心脏代谢风险. 在男性中,HLAP在识别胰岛素耐药性方面表现出卓越的准确性.
科学领域:
- 儿科 儿科 儿科
- 心血管健康 心血管健康
- 代谢健康 代谢健康
背景情况:
- 新兴的指数结合了人体测量和生化测量来进行风险评估.
- 体脂肪指数 (VAI) 和脂质积累产物 (LAP) 正在研究用于预测血压变化 (BP) 和胰岛素抵抗 (IR).
研究的目的:
- 评估VAI和高度校正的LAP (HLAP) 作为巴西青少年心脏代谢风险的预测因素.
- 评估VAI和HLAP对改变BP和IR的预测性能.
主要方法:
- 利用了青少年心血管风险研究 (ERICA) 的数据 (n=37,815,年龄为12-17岁).
- 采用波桑回归来分析VAI/HLAP与改变的BP/IR之间的关联.
- 应用接收器运行特征 (ROC) 曲线分析,以比较预测能力并确定切断点.
主要成果:
- 在研究样本中,改变BP的患病率为24.49%,改变IR的患病率为24.22%.
- 发现VAI和HLAP指数是心脏代谢风险的重要预测指标.
- ROC分析表明了这些指数在识别风险方面的预测能力.
结论:
- VAI和HLAP是预测巴西青少年心脏代谢风险的宝贵工具.
- 在特定于青少年男性的胰岛素耐药性识别方面,HLAP表现出卓越的性能.
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